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The multitude of proteins involved in mammalian metabolism and function of thiamine is not fully characterized

Another natural compound is glycyl-l-histidyl-l-lysine (GHK), a peptide found in human serum and various ECM proteins

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The peptide counteracted picrotoxin (non-competitive GABA receptor Cl channel blocker), isoniazid (inhibitor of glutamic acid decarboxylase and GABA synthesis), and bicuculline (GABA-A antagonist), all through dose-dependent protective effects without producing behavioral changes when administered alone

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