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The mechanisms likely involve both the hormonal disruption of rapid fat loss (fat tissue helps regulate oestrogen and testosterone) and the direct effects of GLP-1 receptor activation on dopamine-mediated sexual motivation

Patients with genetic variants associated with higher GLP-1 receptor sensitivity may experience stronger early appetite suppression, while others report a more gradual onset over 12 weeks

Being dehydrated can have detrimental effects on your overall health

DOI: 10.1158/0008-5472.CAN-04-2253

Conclusion: Bitter melon effectively boosted GLP-1 secretion, leading to better blood sugar control alongside traditional medication