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This conversion creates a recycling pathway known as the citrulline-NO cycle, where NOS (nitric oxide synthase) enzymes transform L-arginine into NO and L-citrulline
B.GojkovicS.KrezicI.MalekinusicD.ZizekH.VuleticL
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We thank all members of the IRB who participated in the DSMB for this study: Katherine Freeman, MPH, Morri Markowitz, MD, Shlomo Shinnar, MD and Mark Sinnett, PharmD
These assessments ensure that beneficial metabolic effects persist and no adverse metabolic changes emerge
Additionally, a multi-country study found substantial demand for GLP-1 medications among people without medical indications, highlighting the evolving landscape of body image and obesity treatment (Jensen et al., 2025)
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