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Epithalon (also known as Epitalon) is a synthetic tetrapeptide investigated in aging-related research, focusing on cellular stress responses, gene expression patterns, and circadian-associated biology in preclinical models

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There is supporting evidence reporting adverse effects from long-term rhIGF-1 treatment including neoplastic formation, cataract and renal hypertrophy, all of which seem to be the most severe effects observed and are usually rare [123, 282284]