Although a BMI around 25 is generally considered desirable, in a patient who was able to reduce BMI from 40 to 32 by therapy with a GLP-1 RA, this may be sufficient to reduce secondary complications
semaglutide once-weekly as add-on therapy to metformin in people with type 2 diabetes (SURPASS-2)
But its unknown if these benefits result from blood glucose control, a reduction in A1C levels, weight loss, or the drug itself
Suppliers offering incremental price breaks at 510 vials and again at 2050 vials are behaving in line with typical CMC and manufacturing realities
In pregnant rats administered semaglutide during organogenesis, embryofetal mortality, structural abnormalities and alterations to growth occurred at maternal exposures below the maximum recommended human dose (MRHD) based on AUC
Its one data point in a bigger sleep picture