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Oxidized redox state of glutathione in the endoplasmic reticulum
Summary: Long-term calorie restriction doesnt appear to directly impact IGF-1 levels in humans, although it may make it less active
Bibcode:2013PLoSO...868490G
Early signs can include increased thirst, more frequent urination, unusual fatigue (especially after meals), and cravings for carbohydrates
AOD9604 had no significant effect in the 3-KO mice
Systemic Administration The choice between local and systemic administration impacts dosage requirements
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