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Environmental factors such as bedroom temperature, bedding materials, and sleepwear should also be evaluated before pursuing extensive medical workup

Importantly, hepatocytes have developed defenses to mitigate the detrimental buildup of ROS within the cell, and GSH-coordinated antioxidant systems, such as catalase, glutathione peroxidase, and superoxide dismutase, play essential roles in this regard ( ROS generated by inflammation can also cause liver injury in addition to cell death caused by mitochondrial malfunction

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Some describe reaching for a glass of wine and setting it down after a sip, feeling indifferent

Sources Institute of Medicine (2005)

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