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Rare: Nausea, headache
Typical dosing: Daily, gradually titrated Common side effects: Nausea, headache, constipation, sleep changes Important note: Non-stimulant option, but not appropriate for some medical conditions or medication histories
This is mechanistically distinct from amphetamine-class compounds: tesofensine doesn't release stored catecholamines
Other outcomes, including stillbirth, spontaneous abortion, small-for-gestational-age births, and preterm birth, showed no statistically significant associations, though several estimates were imprecise and some, like stillbirth, could not fully rule out a clinically meaningful increase
Could these drugs have other uses
The presence of GLP-1 (GLP-1R) and GIP receptors (GIP-R) suggest direct interaction of these agents with EAT
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