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This incidence rate was multiplied by the weighted NHANES population meeting the SOUL trial eligibility criteria to estimate the expected number of MACE events without treatment

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Due to reduced oral contraceptive effectiveness, non-oral or additional contraceptive methods are recommended for 4 weeks after initiating tirzepatide and for 4 weeks after each dose increase

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Acarbose should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus

Factors such as age, overall health, and specific medical conditions like cardiovascular diseases or liver problems may affect suitability for this treatment