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The preservation of NAD+ through NNMT inhibition has profound implications for cellular metabolism

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Vitamin B6, in the form of pyridoxal-5'-phosphate, is the cofactor for 5 enzymes in the -glutamyl cycle and trans-sulphuration pathway: cystathionine -synthase, cystathione -lyase, cytoplasmic and mitochondrial serine hydroxymethyltransferase and glycine decarboxylase in the mitochondria

Our findings indicate that rhein intervention effectively downregulated the levels of adiponectin, leptin, TNF-, and IL-6 in the serum of ORG mice (Figure 2B)

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PubMed Sikiric P, et al