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Evidence caveat: The combination approach is based on clinical observation and mechanistic reasoning, not controlled trials

doi: 10.1186/s13567-022-01025-0 119 LiangJRLingemanELuongTAhmedSMuharMNguyenTet al

Przeom polega na obserwacji, e w obecnoci agonisty GLP-1 wraliwo na GIP moe zosta przywrcona, a oba sygnay dziaaj komplementarnie

Genetics play a role in B12 deficiency Genetic polymorphisms such as MTHFR or MTRR can contribute to low usable B12

In practice, if a therapy is considered, success should be defined with measurable endpointssleep quality, function, waist circumference/body composition (when appropriate), and metabolic markersrather than vague claims alone

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