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A distinction is also made between extra-testicular varicocele (most common) and intra-testicular varicocele

Liver fibrosis is a key marker of MASLD/MASH progression, initiated by elevated hepatocyte expression of pro-fibrotic TFs such as Sox9 and secreted factors such as Spp1 (osteopontin) and Tgfb1 (TGF-1)

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doi: 10.1016/j.biopha.2015.07.034, 56