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However, significant translational barriers remain: no human pharmacokinetic data, high synthesis cost, unknown long-term safety, and the absence of clinical trials

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Clinical laboratories generally define vitamin B12 deficiency as a serum level below 148 pmol/L, which is approximately 200 pg/mL

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While short-term, it may be wise to restrict TMAO-feeding substances such as carnitine and choline, this would obviously not be curative