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These are estimates based on group means
The drug was been approved since 1959 and is used for the following indications: References Mechanism of Action 1,2 Phentermine predominantly acts in the central nervous system (CNS), within the hypothalamus and limbic systems, where it works on appetite regulation
They are typically beyond the early high-response phase of GLP-1 therapy and well into the plateau (typically nine to twelve months in)
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The most commonly reported side effects during the first month are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, consistent with other GLP-1-containing therapies