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They suppress appetite or increase metabolism

Women often notice: Increased abdominal fat, even without changes in diet Slower metabolism and reduced calorie burning Increased insulin resistance Loss of muscle mass Persistent hunger and cravings Difficulty sleeping, which further affects weight regulation These changes are rooted in biology, not willpower

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Children may be given a total of 1 to 5 mg over a period of 2 or more weeks in doses of 100 mcg, then 30 to 50 mcg every 4 weeks for maintenance

Chemogenetic activation of Gipr -expressing neurones in either the hypothalamus or hindbrain decreases food intake in mice, suggesting more than one centrally located population of GIPR neurons regulate appetite 7,8