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A newer drug of this class is semaglutide (sold under the brand name Wegovy), which was approved in 2021 and was found, on average, to reduce weight by 15% in one clinical trial where people took the drug for 68 weeks
Checking lipase makes sense when there are symptoms (severe, persistent abdominal pain, often radiating to the back), not as a standing monitor
10.1016/0006-291X(87)90486-4
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These molecular signaling pathways are critical points influenced by oxidative stress (Sies 2015)
Additionally, rapid weight loss associated with GLP-1 therapy triggers ketosis in some patients, and ketones can produce a fruity or acetone-like smell on the breath
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