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We also demonstrated that the permeability of GSH-targeted nanoparticles was increased across the cARLA-improved human BBB co-culture model [40] improving the predictive value of the current model for BBB penetration

Gassman N

But, this can change based on how bad the deficiency is and what each person needs

Gated mesoporous silica nanoparticles were surface-coated with a peptide that could target TNFR expressed in macrophages after encapsulating DEX inside the silica nanoparticles and injecting it into LPS-induced ALI mice via the tail vein, compared with the group treated with DEX injection alone, its controlled release of DEX, and significant reduction levels of inflammatory factors (TNF- , IL-6, and IL-1) (Garca-Fernndez et al., 2021)

You've done the preliminary work