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GLP-1: central to glycemic control and appetite regulation GLP-1, secreted from intestinal L-cells in response to nutrient intake, exerts its actions via GLP-1 receptors, which are abundantly expressed in pancreatic -cells, the brainstem (notably nucleus tractus solitarius), and the GI tract

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If you begin to notice rising hunger, fatigue, or changes in blood sugar, speak with your doctor early