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The Wnt signaling pathway is mainly mediated by the activation of -catenin and the sustained accumulation of -catenin into the nucleus initiates the transcription of target genes by binding to T-cell factor (TCF)/lymphoid enhancer-binding factor transcription factors (97)

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Umair Hafeez Dr

The study found that these effects were mediated by the activation of GHS-R receptor, as its inhibitor nullified the impact of hexarelin [2]

Stoeltzing et al (109) reported that IGF-I selectively upregulates COX-2 through the MAPK/(ERK1/2) pathway in pancreatic cancer and that treatment with anti-IGF-IR antibodies can effectively inhibit IGF-IR and MAPK/ERK activation and reduce COX-2 expression in parental cells

Pereira NRM et al