"Effectiveness" depends entirely on the research objective maximizing GH amplitude favors HGH, while studying physiological GH patterns favors secretagogues
Yes, some people might need to be careful or avoid Vitamin B12 shots
Brain Res 537:298302
That could create real safety issues
It goes further to explain that the gastric peptide ghrelin is also a potent GH secretagogue that can amplify GHRH secretion, leading to higher growth hormone levels, as seen in the figure below
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