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Following this, the autophagosomes fuse with lysosomes, allowing degradation of the contents and their subsequent return to the cytosol for reuse (140)

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Lastly, the melancholic profile is based on eight items of waking up too early, quality of mood, hypophagia, decreased weight, linkage of mood to time of day (if worse in the morning), view of self, psychomotor agitation and psychomotor retardation (range 024)

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