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These are called exogenous, meaning they come from outside the body, while endogenous antioxidants, like glutathione, are made inside the body
Nebulized glutathione is not used as a treatment for primary lung cancer
Alzahrani TF, Alotaibi SM, Alzahrani AA, Alzahrani AF, Alturki LE, Alshammari MM, Alharbi RA, Alanazi SI, Alshammari WZ, Algarni AS
GSTs conjugate 4HNE to GSH, and the corresponding glutathionyl-4-HNE (GS-HNE) is actively transported out of cells via RLIP76, a multifunctional membrane transporter for GSH-conjugated compounds, and/or MRPs (multidrug-resistance proteins
& Uhlen, M
19 Recent spatial multi-omics studies further support the existence of spatially coordinated ferroptosis-associated programs in injured tubules, with GPX4, ferritin heavy chain 1 (FTH1), and ferritin light chain (FTL) emerging as key spatially enriched markers in regions linked to ferroptotic spread, 93 reinforcing the concept of ferroptosis as a spatially organized tissue response rather than an isolated cellular event
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