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Retatrutide targets three receptors (GIP, GLP-1, and glucagon) compared to two for tirzepatide (GIP and GLP-1) and one for semaglutide (GLP-1)
Split dosing maintains the same total weekly drug exposure
It is a growth hormone-releasing hormone analog without DAC modification, designed for shorter half-life and rapid biological onset
Basal cells begin to divide and migrate upward, leaving behind a single sister cell to form new stem cells
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A phase 3 study (NCT04822181), which enrolled 1200 patients with biopsy-proven MASH and fibrosis, is currently ongoing to assess the benefit of OW subcutaneous semaglutide 2 mg in this setting 93
