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166 On the other hand, an observational study involving 32 postmenopausal women with fibromyalgia found transdermal estradiol plus oral micronized progesterone for 12 weeks resulted in reduced fibromyalgia severity, with a 30% reduction in Fibromyalgia Impact Questionnaire scores, as well as improved sleep and quality of life
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Elevated 2-AG is known to normalize hyperactivation in stress-related brain regions
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