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Comprehensive medical assessment before initiating treatment remains essential, as clinical trial populations never fully represent the diversity of health conditions encountered in practice

Patients with pernicious anaemia or complete malabsorption typically require lifelong treatment at standard intervals, while those with partial malabsorption may have variable needs

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It is essential to rule out clinically significant conditions such as Coeliac disease, Inflammatory Bowel Disease (IBD), or other gastrointestinal pathologies

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