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The underlying mechanism(s) linking reduced IGF-1 signaling to improved mammalian lifespan is thought to involve improved stress defenses and lower risk for proliferative diseases 9,10,11 , though the reason for sex differences in this response remains unresolved

While overall prescribing of semaglutide increased throughout second quarter of 2024, the rate of first-time prescribing of semaglutide slowed from 0.9% of prescriptions in May 2024 to 0.7% in June 2024