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Many people achieve their weight loss goals at 5 mg or 7.5 mg per week, and staying at a lower dose reduces medication costs and side effects simultaneously

The glucagon component appears to be the differentiator

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Studies by Greenwood-Van Meerveld and colleagues using rodent POI models demonstrated that ipamorelin produced dose-dependent improvements in gastric emptying and reversal of POI-induced delayed gastrointestinal transit, with effects mediated through GHS-R1a expressed in gastrointestinal smooth muscle and enteric nervous system tissue

Cardiovascular benefits of semaglutide: a systematic review and meta-analysis of randomized controlled trials