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Insulin has been the recommended ADM during pregnancy, as it does not cross the placenta and is, therefore, unlikely to cause malformations
Arthritis research & therapy
The compound distributes preferentially to metabolically active organs, showing highest concentrations in the kidneys and liver, followed by the stomach wall, thymus, spleen, and intestines
The group receiving a 0.3 mg dose experienced a 6.0% weight loss, with 0.6 mg there was a 6.8% weight loss, with 1.2 mg there was a 9.1% weight loss, with 2.4 mg there was a 9.7% weight loss, and weigh 4.5 mg there was a 10.8% weight loss, compared with 3.0% weight loss for pooled placebo
doi: 10.1038/304368a0 14 HansenLDeaconCFOrskovCHolstJJ
10.1038/s41392-023-01570-w 28 ChenX.SongQ
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