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A randomized trial of a low-trapping nonselective N -methyl-D-aspartate channel blocker in major depression

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Earlier work in Planta Medica by Liu and colleagues demonstrated that madecassoside increases collagen synthesis and reduces inflammatory infiltration in vivo [16]

The latter is a competitor of 2-Oxoglutarate-dependent dioxygenases such as Ten-eleven translocation methylcytosine dioxygenase and therefore induces DNA hydroxymethylation and gene upregulation 52

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Generally, the overall health of the patient must be of reasonable health