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Regarding average changes in HbA1c levels, tirzepatide demonstrated both non-inferiority and superiority to semaglutide at all doses [80, 81]
The non-GLP-1 alternatives matter for patients who cannot tolerate GLP-1s or do not meet eligibility, a unique hedge
Delayed gastric emptying can increase intragastric pressure and potentially promote gastroesophageal reflux, particularly in patients with pre-existing GERD or those who overeat despite reduced appetite signals
Can you microdose GLP-1s safely
They selectively feed Bifidobacteria and Akkermansia, the same microbes that are associated with GLP-1 enhancement
