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Pregnancy Pregnancy Category C Adequate and well-controlled studies have not been done in pregnant women

NCT05394519 ClinicalTrials.gov

NNMT is expressed abundantly in adipose tissue, where it has been associated with fat cell size and lipid storage dynamics

(2020) noted that GHK-Cu possesses prominent antioxidant and anti-inflammatory effects, and that preliminary observations suggest it can partially reverse cognitive impairment in aging mice by targeting anti-inflammatory and epigenetic pathways

Current evidence does not support the use of B12 as a weight loss intervention, and B12 products have no licensed indication for weight loss in the UK

267 While there is a need in clinical research to enroll a more homogeneous patient population, this approach raises concerns about the clinical relevance of such studies for the truly heterogeneous IC/BPS population