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Derm Immuno Today : Are the benefits from GLP-1 RAs in psoriasis independent of weight loss

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GLP-1R agonists may exert antidepressant effects by modulating inflammatory processes in the brain Chronic inflammatory processes in the brain associated with excessive activation of microglia and increased production of pro-inflammatory cytokines are one of the key factors leading to the development of depressive symptoms, as patients suffering from this mental illness are very often characterized by elevated levels of tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), interleukin-1 beta (IL-1), C-reactive protein (CRP), and interferon-gamma (IFN-) in the cerebrospinal fluid and the blood [59,60,61]

Neither pattern has been studied in a published trial

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If Retatrutide shows similar or superior results in its own trials, it could become preferred for patients with both obesity and cardiovascular risk