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The human IGF-1 literature primarily involves mecasermin (native recombinant IGF-1, brand Increlex), approved for growth failure in children with severe IGF-1 deficiency

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To view digital features for this article go to Introduction Obesity (defined as a body mass index [BMI] 30 kg/m 2 in adults [1]) is a major health concern in the USA [2] and is associated with multiple complications, including cardiovascular disease, type 2 diabetes, and osteoarthritis [3,4,5,6,7,8]

Antioxid Redox Signal 15(5):12351253 Boven L, Middel J, Verhoef J, De Groot C, Nottet H (2000) Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV1associated dementia

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