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11 GSH depletion and the subsequent low stores of protein thiol result in both calcium release from intracellular stores and inhibition of calcium extrusion, producing a marked increase in cytosolic calcium concentration, which triggers cytotoxicity

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So, glutathione is involved in the reduction reaction of the ascorbate radical (A) to ascorbate (AH-), catalyzed by the enzyme glutaredoxin [4, 19]

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