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FSP1-mediated reduction of vitamin Kexpanding substrate scope Although CoQ 10 is the primary known substrate of FSP1, emerging evidence indicates that FSP1 exhibits promiscuous substrate specificity
However, rates of these side effects are lower compared with other more common ones, like nausea, vomiting, and diarrhea
It is a plausible mechanism via which GLP-1 may lead to intake suppression since activation of GLP-1 via EX4 injection was shown to decrease the motivation to obtain food (Dickson et al., ad libitum fed rats indicating that this response is robust (Dickson et al., ad libitum condition in which some rats still choose to expend a significant amount of work for their sugar reward (high-responders)
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