Findings presented at ASCO 2025 also showed that the most common any-grade treatment-related adverse effects reported in at least 10% of patients during the randomized portion of the trial included dermatitis acneiform (selumetinib arm, 59%
Larsen NW, Stiles LE, Shaik R, Schneider L, Muppidi S, Tsui CT, et al
Some research has examined investigated effects on adipocyte triglyceride storage, lipolysis markers, and broader lipid handling pathways relevant to the broader adipose research question
Research in animal models has shown significant reductions in body weight and adipose tissue, with studies reporting up to 50% less weight gain in obese Zucker rats after 19 days of administration
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