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To validate our the findings of our study, it will be essential to gather more comprehensive data in the future, ensuring that the designs of upcoming clinical trials routinely incorporate MALE as endpoints
MET forms clusters at excitatory synapses in relatively mature cultured hippocampal neurons and co-localizes with the post-synaptic protein PSD-95 and with the glutamatergic N-methyl-D-aspartate (NMDA) receptor subunit GluN2B (Tyndall and Walikonis, 2006)
More interestingly, this effect is more pronounced in tumor cells with a p53 deficiency (Maddocks et al., 2013)
From a molecular point of view, the necroptosis pathway is initiated by auto- and trans-phosphorylation of RIPK1 and RIPK3 at Ser-227, resulting in stimulation of their kinase activity and assembly of a heterodimer protein complex termed necrosome via their RIPK homotypic interaction motif domains (Oliveira et al., 2018
Hanrahan JP, de Boer IH, Bakris GL et al (2021) Effects of the soluble guanylate cyclase stimulator praliciguat in diabetic kidney disease: a randomized placebo-controlled clinical trial
Persistent vomiting or an inability to keep fluids down, or signs of dehydration such as dizziness, dark urine, or markedly reduced urination
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