Among the GLP-1 analogs, tirzepatide showed the most pronounced decrease in respiratory quotient (RQ) (Fig
Red blood cell production improves, helping prevent anemia: B12 is essential for making healthy red blood cells that carry oxygen throughout the body, and injections can help correct the low levels that lead to fatigue and weakness
Adults with a BMI of 27 or greater who also have at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol
Increased physical activity in combination with reduced caloric intake enables additional weight loss, better glycemic control, and improved insulin sensitivity and lipid profiles (77, 78)
The analysis was performed independently for STEP 1 and STEP 2
In Phase 2 trials, retatrutide produced approximately 24% mean weight loss at 48 weeks at 12 mg, compared with about 22.5% for tirzepatide at 15 mg in the SURMOUNT-1 trial though direct head-to-head data is not yet available