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To overcome these constraints, we propose that future prospective studies implement three key strategies: (1)Systematic collection of dietary and supplemental B12 data using standardized instruments such as food frequency questionnaires

For example, Vitamin B12 injections are often given every 1-2 weeks, while other vitamins may be administered less frequently

Products marketed outside approved channels are not subject to the same quality and safety controls as approved medications, which increases variability and risk

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O'Leary PW, Combs MJ, Schilling RF

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