glutathione and metformin Repurposing for treating osteoarthritis via leveraging Nrf2 signaling Clinical Glutathione demonstrated a 230% improvement of blood ratios Metformin affects macrophages' phenotype and

Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity by activating ERK/Nrf2 antioxidative pathway

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22,23 A second trial of a 74-year-old man with advanced metastatic colon cancer refractory to chemotherapy also evaluated a relatively low dose of 100mg twice daily for six weeks and the patient experienced complete remission of metastases in the lungs and lymph nodes and partial remission of metastasis in the liver

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