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Oxidative damage primarily affects the lysine residue, forming oxidized lysine derivatives that retain partial NF-B inhibition but with altered potency

If tirzepatide can reduce intracranial pressure enough to resolve headaches in IIH, it is plausible that it can reduce pressure enough to lower the migraine threshold in people without a formal IIH diagnosis

2023 Sep;15(9):712-713

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The gut microbiome and Alzheimer 's disease: complex and bidirectional interactions