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Giving a smaller dose of Ozempic or any other GLP-1 can still produce these side effects such as nausea, vomiting, muscle loss, upset stomach, headaches, and slowing of bowel movements potentially leading to ileus or obstruction. George said that microdoses of the drug are only as safe as the pharmacy producing it: To access these custom doses, Noom must use a specialized compounding pharmacy

Hyperpigmentation, characterized by patches of darkened skin, is a source of concern for individuals seeking to achieve a more even complexion

Rice Sci 30(1):7086

However, as we age, the levels of glutathione decrease, leading to common skin issues like dullness, sagging, and wrinkles

In contrast, the GLP-1 receptor KO mice had higher AUC glucose than the other groups after 25 and 50 mg, but this was mainly related to the higher fasting glucose, which most likely is a phenomenon explained by exaggerated hepatic glucose production due to absence of GLP-1 action to inhibit liver glucose production, which has been demonstrated in rodents (19) and humans (20, 21) and which may be mediated by insulin and glucagon, but also mediated by GLP-1 receptors located in the portal system (22, 23)

Symptoms to watch for include severe abdominal pain, particularly in the upper right side, fever, and jaundice