The phenomenon is called the bone fragility diabetes paradox, indicating that other factors besides BMD may affect fracture risk
Regarding lactation, there are no data on tirzepatide presence in human milk, effects on the breastfed infant, or effects on milk production
Transcriptomic analysis and experimental validation revealed that PS-MPs exposure significantly increased SIRT4 expression in mouse oocytes
Structural studies of retatrutide bound to GLP-1R, GIPR, and GCGR have been deposited in the Protein Data Bank, supporting docking, mutagenesis, and structure-activity work in computational pharmacology
However, it remains unlicensed in the UK not approved by the MHRA or EMA meaning robust, sex-specific safety data are still limited
doi: 10.1016/j.juro.2008.10.015 46 WongWYMerkusHMThomasCMMenkveldRZielhuisGASteegers-TheunissenRP