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Staying hydrated, eating smaller frequent meals, and avoiding high-fat foods during early weeks minimizes gastrointestinal upset

BMJ report date: May 19, 2026 Health Canada first generic authorization: April 28, 2026 Dr

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Key takeaway Both medicines can support significant weight loss, especially at the higher, weight-management doses (Wegovy for semaglutide and Zepbound for tirzepatide)

They show how much muscle versus fat is lost and where fat is lost from

Dysesthesia occurred in 5.1% (4 mg), 12.3% (9 mg), and 12.5% (12 mg) of patients treated with retatrutide, compared to 0.9% with placebo, although this was generally mild to moderate and resolved during treatment