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However, there is still a significant difference between the WL that can be achieved with bariatric surgery and the currently approved obesity pharmacotherapies and there is heterogeneity in treatment responses with GLP-1 RA (for example people with T2D may achieve less WL compared to those without diabetes in clinical trials, despite similar lifestyle interventions) [13, 14]

Can semaglutide GLP-1 help with long-term weight management

Each cycle of loss and regain may worsen metabolic adaptation, making subsequent weight loss harder and regain faster