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In this study, NLRP3 inflammasome was activated in N9 murine microglia via 1 g/ml LPS (Lipopolysaccharide) for 4 h and 5 mM ATP (Adenosine 5-triphosphate) for 1 h, respectively

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Titration Design In the Phase 2 trial published in The New England Journal of Medicine , participants started on a low introductory dose (as little as 24 mg weekly) and were titrated upward over the course of several weeks before reaching target doses of 812 mg

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