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The PDB file of the crystal structure of the ligand molecule obtained in the previous step was downloaded and saved

The continuous hyperglycemia can induce target organ damage (TOD) by increasing the risk of panvascular disease, including microvascular disease (such as diabetic retinopathy, nephropathy and neuropathy), and atherosclerotic macrovascular disease (cardiovascular, cerebrovascular, and other peripheral vascular diseases)

Burghardt Neuropsychopharmacology.2019

10.1016/j.bbagen.2009.01.007 72 Romero-MrquezJ

BDNF provides many routes toward STN DBS-mediated disease modification

Additionally, other factors such as having had gastric bypass surgery or taking antacids long-term can lead to deficiency