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In hypoxic epithelial ovarian cancer, as a transcription factor of IGF-1, highly expressed ELF3-mediated secretion of IGF-1 and VEGF promoted endothelial cell proliferation, migration and tumor angiogenesis through activation of the tyrosine kinase pathway, whereas ELF3 silencing attenuated angiogenesis and tumorigenesis in a xenograft mouse model, demonstrating the pro-vascular effect of IGF-1 (39)

Preliminary studies suggest that inhibiting ferroptosis may offer protective effects on ovarian function, although the translational relevance of these findings remains to be established

For example, short acting insulin or basal insulin adjustments can address gaps while oral agents are held

Options include other GLP-1 agonists, GLP-1/GIP dual agonists, and emerging triple agonists like retatrutide

Chevy Chase, MD

NovoLog and foods There arent any foods that have been specifically reported to interact with NovoLog