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This complex symptomatology reflects the widespread and multisystem nature of PD pathology, which extends far beyond the basal ganglia to involve cortical, limbic, and peripheral autonomic structures [3, 4]

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The branded version was discontinued in 2008, and Sermorelin is currently dispensed only through licensed compounding pharmacies

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Recently, ultradeformable liposomes (UL) have been developed by scientific researchers, which greatly increased the skin permeation ability of rosmarinic acid by UL containing oleic acid, exhibiting potential as a formulation for development for external use (Subongkot et al., 2021)

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