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Furthermore, a multinational cohort study involving five countries revealed that neither insulin detemir nor insulin glargine significantly increases cancer risk compared to human insulin [107]

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When to seek urgent medical attention (contact 999 or attend A&E): Severe, persistent abdominal pain with fever (possible pancreatitis) Signs of allergic reaction : difficulty breathing, facial swelling, severe rash High fever (39C) with severe symptoms Signs of severe infection : confusion, rapid breathing, chest pain When to contact your GP or NHS 111 (same day or next available appointment): Moderate fever (3839C) lasting more than 48 hours Abdominal pain (especially right upper quadrant) with fever Jaundice (yellowing of skin or eyes) Injection site infection : increasing redness, warmth, swelling, or pus Persistent vomiting or diarrhoea with fever leading to dehydration Regarding Saxenda continuation: You should temporarily withhold Saxenda and seek medical advice if you develop severe systemic illness, suspected severe allergic reaction, significant dehydration, or symptoms of pancreatitis

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